Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Transcription Factor AP4 Promotes Oncogenic Phenotypes and Cisplatin Resistance by Regulating LAPTM4B Expression.

Molecular cancer research : MCR - 1 May 2018

Wang Lu, Meng Yue, Xu Jian-Jun, Zhang Qing-Yun

Abstract excerpt

Lysosomal-associated protein transmembrane-4 beta (LAPTM4B) is a novel oncogene, whose overexpression is involved in cancer occurrence and progression. However, the mechanism of LAPTM4B transcriptional regulation remains unclear. In this study, the results of transcription factor (TF) profiling plate arrays indicated that AP4 was a potential transcription factor regulating LAPTM4B expression. LAPTM4B was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Share to Carcinogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cisplatin

Share to Heterografts

Share to MCF-7 Cells

Share to Mice, Inbred NOD

Share to Mice, SCID

Share to Oncogene Proteins

Source

Identifiers

PMID: 29378908
DOI: 10.1158/1541-7786.MCR-17-0519

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Transcription Factor AP4 Promotes Oncogenic Phenotypes and Cisplatin Resistance by Regulating LAPTM4B Expression.PMID 29378908Read ↗

LAPTM4B: an oncogene in various solid tumors and its functions.Semantic proximity Read ↗

LAPTM4B allele *2 is associated with breast cancer susceptibility and prognosis.Semantic proximity Read ↗

A comprehensive prognostic and immune analysis of LAPTM4B in pan-cancer and Philadelphia chromosome-positive acute lymphoblastic leukemiaSemantic proximity Read ↗

Association of LAPTM4B gene polymorphism with breast cancer susceptibility.Semantic proximity Read ↗

LAPTM4B polymorphism increases susceptibility to multiple cancers in Chinese populations: a meta-analysis.Semantic proximity Read ↗

LAPTM4B polymorphisms is associated with ovarian cancer susceptibility and its prognosis.Semantic proximity Read ↗

LAPTM4B gene polymorphism and endometrial carcinoma risk and prognosis.Semantic proximity Read ↗

Correlation of LAPTM4B polymorphisms with cervical carcinoma.Semantic proximity Read ↗

TFAP2A downregulation mediates tumor-suppressive effect of miR-8072 in triple-negative breast cancer via inhibiting SNAI1 transcriptionSemantic proximity Read ↗

AP4 is a mediator of epithelial–mesenchymal transition and metastasis in colorectal cancerSemantic proximity Read ↗

LAPTM5 regulated by FOXP3 promotes the malignant phenotypes of breast cancer through activating the Wnt/β‑catenin pathway.Semantic proximity Read ↗

The prolactin receptor transactivation domain is associated with steroid hormone receptor expression and malignant progression of breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.