Article
LAPTM4B allele *2 is associated with breast cancer susceptibility and prognosis.
PloS one - 1 Jan 2012
Li Xiaoyan, Kong Xiangnan, Chen Xi, Zhang Ning, Jiang Liyu, Ma Tingting, Yang Qifeng
Abstract excerpt
BACKGROUND: Lysosome-associated protein transmembrane 4 beta (LAPTM4B) has two alleles named LAPTM4B*1 and LAPTM4B*2. Allele *1 contains only one copy of a 19-bp sequence at the 5'UTR in the first exon, whereas this sequence of allele*2 is duplicated and arrayed as a tandem repeat. Previous studies revealed that LAPTM4B polymorphisms contribute to the risk of certain types of cancers. This study aimed to...
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