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CodY Deletion Enhances <i>In Vivo</i> Virulence of Community-Associated Methicillin-Resistant Staphylococcus aureus Clone USA300

24 Apr 2012

Abstract excerpt

The Staphylococcus aureus global regulator CodY responds to nutrient availability by controlling the expression of target genes. In vitro, CodY represses the transcription of virulence genes, but it is not known if CodY also represses virulence in vivo. The dominant community-associated methicillin-resistant S. aureus (CA-MRSA) clone, USA300, is hypervirulent and has increased transcription of global regulators...

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PMID: 22526672
DOI: 10.1128/iai.06172-11

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