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Article

Targeting the CACNA1A IRES as a Treatment for Spinocerebellar Ataxia Type 6.

Cerebellum (London, England) - 1 Feb 2018

Pastor Parviz Daniel Hejazi, Du Xiaofei, Fazal Sarah, Davies Andre N, Gomez Christopher M

Abstract excerpt

We have discovered that the P/Q-type voltage-gated Ca2+ channel (VGCC) gene, CACNA1A, encodes both the α1A (Cav2.1) subunit and a newly recognized transcription factor, α1ACT, by means of a novel internal ribosomal entry site (IRES) within the α1A C-terminal coding region. α1ACT, when mutated with an expansion of the polyglutamine tract in the C-terminus, gives rise to spinocerebellar ataxia type 6 (SCA6)....

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Identifiers

PMID: 29374372
DOI: 10.1007/s12311-018-0917-6
PMCID: PMC5809202

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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