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Article

Splice isoform-specific suppression of the Cav2.1 variant underlying spinocerebellar ataxia type 6.

Neurobiology of disease - 1 Sept 2011

Tsou Wei-Ling, Soong Bing-Wen, Paulson Henry L, Rodríguez-Lebrón Edgardo

Abstract excerpt

Spinocerebellar ataxia type 6 (SCA6) is an inherited neurodegenerative disease caused by a polyglutamine (polyQ) expansion in the Ca(V)2.1 voltage-gated calcium channel subunit (CACNA1A). There is currently no treatment for this debilitating disorder and thus a pressing need to develop preventative therapies. RNA interference (RNAi) has proven effective at halting disease progression in several models of...

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Identifiers

PMID: 21550405
DOI: 10.1016/j.nbd.2011.04.016
PMCID: PMC3169420

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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