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Article

Changes in expression of klotho affect physiological processes, diseases, and cancer.

1 Jan 2018

Abstract excerpt

OBJECTIVES: In the present study, a new series of 6-methoxy-2-arylquinoline analogues was designed and synthesized as P-glycoprotein (P-gp) inhibitors using quinine and flavones as the lead compounds. MATERIALS AND METHODS: The cytotoxic activity of the synthesized compounds was evaluated against two human cancer cell lines including EPG85-257RDB, multidrug-resistant gastric carcinoma cells (P-gp-positive gastric...

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PMID: 29372030
DOI: 10.22038/ijbms.2017.21892.5616

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