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Article

Chemoprevention in Patients with Peutz-Jeghers Syndrome: Lessons Learned.

The oncologist - 1 Apr 2018

de Brabander Justin, Eskens Ferry A L M, Korsse Susanne E, Dekker Evelien, Dewint Pieter, van Leerdam Monique E, van Eeden Susanne, Klümpen Heinz-Josef

Abstract excerpt

LESSONS LEARNED: Motivating patients to enroll in chemopreventive studies is challenging.Chemoprevention with toxic drugs is not feasible. BACKGROUND: LKB1 mutations are the underlying genetic abnormality causing Peutz-Jeghers syndrome (PJS) and are a potential target for everolimus. In this phase II study, the efficacy of everolimus on polyp and tumor growth in PJS patients was investigated. METHODS: Adult...

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Identifiers

PMID: 29371475
DOI: 10.1634/theoncologist.2017-0682
PMCID: PMC5896716

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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