Article
Structure-function analyses generate novel specificities to assemble the components of multienzyme bacterial cellulosome complexes.
The Journal of biological chemistry - 16 Mar 2018
Bule Pedro, Cameron Kate, Prates José A M, Ferreira Luís M A, Smith Steven P, Gilbert Harry J, Bayer Edward A, Najmudin Shabir, Fontes Carlos M G A, Alves Victor D
Abstract excerpt
The cellulosome is a remarkably intricate multienzyme nanomachine produced by anaerobic bacteria to degrade plant cell wall polysaccharides. Cellulosome assembly is mediated through binding of enzyme-borne dockerin modules to cohesin modules of the primary scaffoldin subunit. The anaerobic bacterium Acetivibrio cellulolyticus produces a highly intricate cellulosome comprising an adaptor scaffoldin, ScaB, whose...
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