Article
Functional insights into the role of novel type I cohesin and dockerin domains from Clostridium thermocellum.
The Biochemical journal - 10 Dec 2009
Pinheiro Benedita A, Gilbert Harry J, Sakka Kazutaka, Sakka Kazuo, Fernandes Vânia O, Prates José A M, Alves Victor D, Bolam David N, Ferreira Luís M A, Fontes Carlos M G A
Abstract excerpt
Cellulosomes, synthesized by anaerobic microorganisms such as Clostridium thermocellum, are remarkably complex nanomachines that efficiently degrade plant cell wall polysaccharides. Cellulosome assembly results from the interaction of type I dockerin domains, present on the catalytic subunits, and the cohesin domains of a large non-catalytic integrating protein that acts as a molecular scaffold. In general, type...
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