KRAS and BRAF mutations in circulating tumour DNA from locally advanced rectal cancer.

doi:10.1038/s41598-018-19212-5

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

KRAS and BRAF mutations in circulating tumour DNA from locally advanced rectal cancer.

Scientific reports - 23 Jan 2018

Sclafani Francesco, Chau Ian, Cunningham David, Hahne Jens C, Vlachogiannis George, Eltahir Zakaria, Lampis Andrea, Braconi Chiara, Kalaitzaki Eleftheria, De Castro David Gonzalez, Wotherspoon Andrew, Capdevila Jaume, Glimelius Bengt, Tarazona Noelia, Begum Ruwaida, Lote Hazel, Hulkki Wilson Sanna, Mentrasti Giulia, Brown Gina, Tait Diana, Oates Jacqueline, Valeri Nicola

Abstract excerpt

There are limited data on circulating, cell-free, tumour (ct)DNA analysis in locally advanced rectal cancer (LARC). Digital droplet (dd)PCR was used to investigate KRAS/BRAF mutations in ctDNA from baseline blood samples of 97 LARC patients who were treated with CAPOX followed by chemoradiotherapy, surgery and adjuvant CAPOX ± cetuximab in a randomised phase II trial. KRAS mutation in G12D, G12V or G13D was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Combined Chemotherapy Protocols

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Capecitabine

Share to Cetuximab

Share to Circulating Tumor DNA

Share to Organoplatinum Compounds

Share to Oxaliplatin

Share to Proto-Oncogene Proteins p21(ras)

Share to Rectal Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 29362371
DOI: 10.1038/s41598-018-19212-5
PMCID: PMC5780472

Genes

KRAS
BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

KRAS and BRAF mutations in circulating tumour DNA from locally advanced rectal cancer.PMID 29362371Read ↗

KRAS G12V Mutation Detection by Droplet Digital PCR in Circulating Cell-Free DNA of Colorectal Cancer Patients.Semantic proximity Read ↗

Detection of Somatic Mutations with ddPCR from Liquid Biopsy of Colorectal Cancer Patients.Semantic proximity Read ↗

Detection of mutations in circulating cell‐free DNA in relation to disease stage in colorectal cancerSemantic proximity Read ↗

Detection of KRAS, NRAS and BRAF Mutations in Liquid Biopsy from Patients with Colorectal Cancer.Semantic proximity Read ↗

Detection of KRAS mutations in circulating tumour DNA from plasma and urine of patients with colorectal cancer.Semantic proximity Read ↗

Detection of KRAS mutations in liquid biopsies from metastatic colorectal cancer patients using droplet digital PCR, Idylla, and next generation sequencingSemantic proximity Read ↗

Ultra-low Input Circulating Tumor DNA Detection by MED-Amp in Early-Stage Pancreatic CancerSemantic proximity Read ↗

Performance of four platforms for KRAS mutation detection in plasma cell-free DNA: ddPCR, Idylla, COBAS z480 and BEAMing.Semantic proximity Read ↗

Detection of <i>KRAS, NRAS</i> and <i>BRAF</i> mutations in liquid biopsy from patients with colorectal cancerSemantic proximity Read ↗

An improved digital polymerase chain reaction protocol to capture low-copy KRAS mutations in plasma cell-free DNA by resolving 'subsampling' issues.Semantic proximity Read ↗

Measuring KRAS Mutations in Circulating Tumor DNA by Droplet Digital PCR and Next-Generation SequencingSemantic proximity Read ↗

Clinicopathological factors associated with tumour-specific mutation detection in plasma of patients with RAS-mutated or BRAF-mutated metastatic colorectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.