Article
Genetic and epigenetic biomarkers in cancer : improving diagnosis, risk assessment, and disease stratification.
Molecular diagnosis & therapy - 1 Jan 2006
Verma Mukesh, Seminara Daniela, Arena Fernando J, John Christy, Iwamoto Kumiko, Hartmuller Virginia
Abstract excerpt
Gene expression patterns change during the initiation, progression, and development of cancer, as a result of both genetic and epigenetic mechanisms. Genetic changes arise due to irreversible changes in the nucleotide sequence, whereas epigenetic changes occur due to changes in chromatin conformation, histone acetylation, and methylation of the CpG islands located primarily in the promoter region of a gene. Both...
Topics
- Biomarkers, Tumor
- DNA Methylation
- Epigenesis, Genetic
- Genetic Markers
- Genetic Predisposition to Disease
- Humans
- Neoplasms