Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional analysis of thyroid hormone receptor beta in Xenopus tropicalis founders using CRISPR-Cas

1 Jan 2017

Abstract excerpt

Amphibians provide an ideal model to study the actions of thyroid hormone (TH) in animal development because TH signaling via two TH receptors, TRα and TRβ, is indispensable for amphibian metamorphosis. However, specific roles for the TRβ isoform in metamorphosis are poorly understood. To address this issue, we generated trβ-disrupted Xenopus tropicalis tadpoles using the CRISPR-Cas system. We first established a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Physiological and biochemical adaptations
Share to Thyroid Disorders and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29358165
DOI: 10.1242/bio.030338

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional analysis of thyroid hormone receptor beta in Xenopus tropicalis founders using CRISPR-CasPMID 29358165Read ↗

Thyroid Hormone Receptor Is Essential for Larval Epithelial Apoptosis and Adult Epithelial Stem Cell Development but Not Adult Intestinal Morphogenesis during Xenopus tropicalis MetamorphosisSemantic proximity Read ↗

Role of Thyroid Hormone Receptor in Amphibian Development.Semantic proximity Read ↗

Organ-Specific Requirements for Thyroid Hormone Receptor Ensure Temporal Coordination of Tissue-Specific Transformations and Completion of Xenopus MetamorphosisSemantic proximity Read ↗

Organ‐specific effects on target binding due to knockout of thyroid hormone receptor α during Xenopus metamorphosisSemantic proximity Read ↗

Growth, Development, and Intestinal Remodeling Occurs in the Absence of Thyroid Hormone Receptor α in Tadpoles of Xenopus tropicalis.Semantic proximity Read ↗

Unliganded thyroid hormone receptor α regulates developmental timing via gene repression in Xenopus tropicalis.Semantic proximity Read ↗

Regulation of growth rate and developmental timing by Xenopus thyroid hormone receptor αSemantic proximity Read ↗

Analysis of Thyroid Hormone Receptor α-Knockout Tadpoles Reveals That the Activation of Cell Cycle Program Is Involved in Thyroid Hormone-Induced Larval Epithelial Cell Death and Adult Intestinal Stem Cell Development During Xenopus tropicalis MetamorphosisSemantic proximity Read ↗

Life Without Thyroid Hormone ReceptorSemantic proximity Read ↗

Development and metamorphosis in frogs deficient in the thyroid hormone transporter MCT8.Semantic proximity Read ↗

A Simple Protocol for Loss-of-Function Analysis in Xenopus tropicalis Founders Using the CRISPR-Cas System.Semantic proximity Read ↗

Thyroid hormone receptor knockout prevents the loss of Xenopus tail regeneration capacity at metamorphic climaxSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.