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Article

Prognostic and predictive role of EGFR pathway alterations in biliary cancer patients treated with chemotherapy and anti-EGFR.

PloS one - 1 Jan 2018

Peraldo-Neia Caterina, Cavalloni Giuliana, Fenocchio Elisabetta, Cagnazzo Celeste, Gammaitoni Loretta, Cereda Stefano, Nasti Guglielmo, Satolli Maria Antonietta, Aprile Giuseppe, Reni Michele, Avallone Antonio, Spadi Rosella, Venesio Tiziana, Martin Vittoria, Doglioni Claudio, Frattini Milo, Aglietta Massimo, Leone Francesco

Abstract excerpt

The association of anti-EGFR to gemcitabine and oxaliplatin (GEMOX) chemotherapy did not improve survival in biliary tract carcinoma (BTC) patients. Multiple mechanisms might be involved in the resistance to anti-EGFR. Here, we explored the mutation profile of EGFR extracellular domain (ECD), of tyrosine kinase domain (TKD), and its amplification status. EGFR mutational status of exons 12, 18-21 was analyzed in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29352306
DOI: 10.1371/journal.pone.0191593
PMCID: PMC5774843

Genes

EGFR
ECD
BTC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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