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Article

p53 Mediates Autophagy and Cell Death by a Mechanism Contingent On Bnip3

7 May 2013

Abstract excerpt

Myocardial ischemia and angiotensin II activate the tumor suppressor p53 protein, which promotes cell death. Previously, we showed that the Bcl-2 death gene Bnip3 is highly induced during ischemia, where it triggers mitochondrial perturbations resulting in autophagy and cell death. However, whether p53 regulates Bnip3 and autophagy is unknown. Herein, we provide new compelling evidence for a novel signaling axis...

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PMID: 23648705
DOI: 10.1161/hypertensionaha.113.01028

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