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Article

Variation at position 350 in the Chikungunya virus 6K-E1 protein determines the sensitivity of detection in a rapid E1-antigen test.

Scientific reports - 18 Jan 2018

Tuekprakhon Aekkachai, Nakayama Emi E, Bartholomeeusen Koen, Puiprom Orapim, Sasaki Tadahiro, Huits Ralph, Luplertlop Natthanej, Kosoltanapiwat Nathamon, Maneekan Pannamas, Ariën Kevin K, Shioda Tatsuo, Leaungwutiwong Pornsawan

Abstract excerpt

Chikungunya virus (CHIKV), a mosquito-borne pathogen, consists of three genotypes: East/Central/South African (ECSA), West African (WA), and Asian. Although a current rapid immunochromatographic (IC) test detecting CHIKV E1-antigen showed high sensitivity to ECSA-genotype viruses, it showed poor performance against the Asian-genotype virus that is spreading in the American continents. To understand the basis for...

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Identifiers

PMID: 29348674
DOI: 10.1038/s41598-018-19174-8
PMCID: PMC5773492

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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