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Article

The microbiota metabolite indole inhibits Salmonella virulence: Involvement of the PhoPQ two-component system

17 Jan 2018

Abstract excerpt

The microbial community present in the gastrointestinal tract is an important component of the host defense against pathogen infections. We previously demonstrated that indole, a microbial metabolite of tryptophan, reduces enterohemorrhagic Escherichia coli O157:H7 attachment to intestinal epithelial cells and biofilm formation, suggesting that indole may be an effector/attenuator of colonization for a number of...

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PMID: 29342189
DOI: 10.1371/journal.pone.0190613

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