Article
Genetic variation of GRIA3 gene is associated with vulnerability to methamphetamine dependence and its associated psychosis.
Journal of psychopharmacology (Oxford, England) - 1 Mar 2018
Iamjan Sri-Arun, Thanoi Samur, Watiktinkorn Paritat, Reynolds Gavin P, Nudmamud-Thanoi Sutisa
Abstract excerpt
Methamphetamine (METH) is an addictive psychostimulant drug commonly leading to schizophrenia-like psychotic symptoms. Disturbances in glutamatergic neurotransmission have been proposed as neurobiological mechanisms and the α-amino-3 hydroxy-5 methyl-4 isoxazole propionic acid (AMPA) glutamate receptor has been implicated in these processes. Moreover, genetic variants in GRIAs, genes encoding AMPA receptor...
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