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Article

SIRT1-Regulated Abnormal Acetylation of FOXP3 Induces Regulatory T-Cell Function Defect in Hashimoto's Thyroiditis

16 Jan 2018

Abstract excerpt

Background: Hashimoto's thyroiditis (HT) is an autoimmune thyroid disease characterized by low expression of transcription factor Forkhead Box P3 (FOXP3) and functional deficiency of a cluster of differentiation regulatory T cells (Tregs). This study aimed to investigate the mechanism of Treg dysfunction in HT. Methods: The number of CD4+CD25+FOXP3+ T cells was determined by flow cytometry. Expression of FOXP3...

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PMID: 29336238
DOI: 10.1089/thy.2017.0286

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