Article
Reconstructing an African haploid genome from the 18th century.
Nature genetics - 1 Feb 2018
Jagadeesan Anuradha, Gunnarsdóttir Ellen D, Ebenesersdóttir S Sunna, Guðmundsdóttir Valdis B, Thordardottir Elisabet Linda, Einarsdóttir Margrét S, Jónsson Hákon, Dugoujon Jean-Michel, Fortes-Lima Cesar, Migot-Nabias Florence, Massougbodji Achille, Bellis Gil, Pereira Luisa, Másson Gísli, Kong Augustine, Stefánsson Kári, Helgason Agnar
Abstract excerpt
A genome is a mosaic of chromosome fragments from ancestors who existed some arbitrary number of generations earlier. Here, we reconstruct the genome of Hans Jonatan (HJ), born in the Caribbean in 1784 to an enslaved African mother and European father. HJ migrated to Iceland in 1802, married and had two children. We genotyped 182 of his 788 descendants using single-nucleotide polymorphism (SNP) chips and...
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