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Article

Inhibition of Drp1/Fis1 interaction slows progression of amyotrophic lateral sclerosis.

EMBO molecular medicine - 1 Mar 2018

Joshi Amit U, Saw Nay L, Vogel Hannes, Cunnigham Anna D, Shamloo Mehrdad, Mochly-Rosen Daria

Abstract excerpt

Bioenergetic failure and oxidative stress are common pathological hallmarks of amyotrophic lateral sclerosis (ALS), but whether these could be targeted effectively for novel therapeutic intervention needs to be determined. One of the reported contributors to ALS pathology is mitochondrial dysfunction associated with excessive mitochondrial fission and fragmentation, which is predominantly mediated by Drp1...

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Identifiers

PMID: 29335339
DOI: 10.15252/emmm.201708166
PMCID: PMC5840540

Genes

SOD1

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