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Prevention of mitochondrial impairment by inhibition of protein phosphatase 1 activity in amyotrophic lateral sclerosis.

Cell death & disease - 21 Oct 2020

Choi So Yoen, Lee Ju-Hyun, Chung Ah-Young, Jo Youhwa, Shin Joo-Ho, Park Hae-Chul, Kim Hyun, Lopez-Gonzalez Rodrigo, Ryu Jae Ryun, Sun Woong

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by progressive loss of motor neurons (MNs) and subsequent muscle weakness. These pathological features are associated with numerous cellular changes, including alteration in mitochondrial morphology and function. However, the molecular mechanisms associating mitochondrial structure with ALS pathology are poorly understood. In this...

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Identifiers

PMID: 33087694
DOI: 10.1038/s41419-020-03102-8
PMCID: PMC7578657

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