Article
AZD9291 Increases Sensitivity to Radiation in PC-9-IR Cells by Delaying DNA Damage Repair after Irradiation and Inducing Apoptosis.
Radiation research - 1 Mar 2018
Wu Shenghai, Zhu Lucheng, Tu Linglan, Chen Sumei, Huang Haixiu, Zhang Jingjing, Ma Shenglin, Zhang Shirong
Abstract excerpt
AZD9291 is a novel, irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), which is administered orally. It has been proven effective in non-small cell lung cancer (NSCLC) patients, with both EGFR-sensitizing and EGFR T790M mutations in preclinical models. However, the potential therapeutic effects of AZD9291 combined with other modalities, including ionizing radiation, are not well...
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