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Article

Afatinib increases sensitivity to radiation in non-small cell lung cancer cells with acquired EGFR T790M mutation.

Oncotarget - 20 Mar 2015

Zhang Shirong, Zheng Xiaoliang, Huang Haixiu, Wu Kan, Wang Bing, Chen Xufeng, Ma Shenglin

Abstract excerpt

Afatinib is a second-generation of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor and has shown a significant clinical benefit in non-small cell lung cancer (NSCLC) patients with EGFR-activating mutations. However, the potential therapeutic effects of afatinib combining with other modalities, including ionizing radiation (IR), are not well understood. In this study, we developed a...

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Identifiers

PMID: 25714021
DOI: 10.18632/oncotarget.3332
PMCID: PMC4467405

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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