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Article

Overcoming Acquired Resistance to AZD9291, A Third-Generation EGFR Inhibitor, through Modulation of MEK/ERK-Dependent Bim and Mcl-1 Degradation.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2017

Shi Puyu, Oh You-Take, Deng Liang, Zhang Guojing, Qian Guoqing, Zhang Shuo, Ren Hui, Wu Grant, Legendre Benjamin, Anderson Emily, Ramalingam Suresh S, Owonikoko Taofeek K, Chen Mingwei, Sun Shi-Yong

Abstract excerpt

Purpose: The mechanisms accounting for anticancer activity of AZD9291 (osimertinib or TAGRISSO), an approved third-generation EGFR inhibitor, in EGFR-mutant non-small cell lung cancer (NSCLC) cells and particularly for the subsequent development of acquired resistance are unclear and thus are the focus of this study.Experimental Design: AZD9219-resistant cell lines were established by exposing sensitive cell...

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Identifiers

PMID: 28765329
DOI: 10.1158/1078-0432.CCR-17-1574
PMCID: PMC5668147

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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