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Article

Chemical genomic guided engineering of gamma-valerolactone tolerant yeast.

Microbial cell factories - 12 Jan 2018

Bottoms Scott, Dickinson Quinn, McGee Mick, Hinchman Li, Higbee Alan, Hebert Alex, Serate Jose, Xie Dan, Zhang Yaoping, Coon Joshua J, Myers Chad L, Landick Robert, Piotrowski Jeff S

Abstract excerpt

BACKGROUND: Gamma valerolactone (GVL) treatment of lignocellulosic bomass is a promising technology for degradation of biomass for biofuel production; however, GVL is toxic to fermentative microbes. Using a combination of chemical genomics with the yeast (Saccharomyces cerevisiae) deletion collection to identify sensitive and resistant mutants, and chemical proteomics to monitor protein abundance in the presence...

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Identifiers

PMID: 29329531
DOI: 10.1186/s12934-017-0848-9
PMCID: PMC5767017

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