Article
Generalization of the Ewens sampling formula to arbitrary fitness landscapes.
PloS one - 1 Jan 2018
Khromov Pavel, Malliaris Constantin D, Morozov Alexandre V
Abstract excerpt
In considering evolution of transcribed regions, regulatory sequences, and other genomic loci, we are often faced with a situation in which the number of allelic states greatly exceeds the size of the population. In this limit, the population eventually adopts a steady state characterized by mutation-selection-drift balance. Although new alleles continue to be explored through mutation, the statistics of the...
Topics
- Alleles
- Models, Genetic
- Mutation
- Transcription, Genetic