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Article

TALEN-mediated shift of mitochondrial DNA heteroplasmy in MELAS-iPSCs with m.13513G>A mutation.

Scientific reports - 14 Nov 2017

Yahata Naoki, Matsumoto Yuji, Omi Minoru, Yamamoto Naoki, Hata Ryuji

Abstract excerpt

Induced pluripotent stem cells (iPSCs) are suitable for studying mitochondrial diseases caused by mitochondrial DNA (mtDNA) mutations. Here, we generated iPSCs from a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) with the m.13513G>A mutation. The patient's dermal fibroblasts were reprogrammed, and we established two iPSC clones with and without mutant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29138463
DOI: 10.1038/s41598-017-15871-y
PMCID: PMC5686150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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