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Article

A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans.

Nature communications - 8 Jan 2018

Zhang Guoliang, deWeerd Nicole A, Stifter Sebastian A, Liu Lei, Zhou Boping, Wang Wenfei, Zhou Yiping, Ying Binwu, Hu Xuejiao, Matthews Antony Y, Ellis Magda, Triccas James A, Hertzog Paul J, Britton Warwick J, Chen Xinchun, Feng Carl G

Abstract excerpt

Type I interferons (IFN), best known for their anti-viral functions, have been shown to impair host resistance to intracellular bacteria in mice. However, the precise role of type I IFN signaling in bacterial infection in humans is unclear. Here, we show that genetic variation in the human IFNAR1 gene is associated with decreased susceptibility to tuberculosis and an increased risk of viral hepatitis in Chinese...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29311663
DOI: 10.1038/s41467-017-02611-z
PMCID: PMC5758831

Genes

IFNAR1

Provenance

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