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Article

Destabilization of the transmembrane domain induces misfolding in a phenotypic mutant of cystic fibrosis transmembrane conductance regulator.

The Journal of biological chemistry - 11 Feb 2005

Choi Mei Y, Partridge Anthony W, Daniels Craig, Du Kai, Lukacs Gergely L, Deber Charles M

Abstract excerpt

Two phenotypic missense mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) channel pore (L346P and R347P in transmembrane (TM) segment 6) involve gain of a proline residue, but only L346P represents a significant loss of segment hydropathy. We show here that, for syntheti...

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Source

Identifiers

PMID: 15537638
DOI: 10.1074/jbc.M410069200

Genes

CFTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15537638-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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