Article
Genotype-based recall to study metabolic effects of genetic variation: a pilot study of PPARG Pro12Ala carriers.
Upsala journal of medical sciences - 1 Nov 2017
Kamble Prasad G, Gustafsson Stefan, Pereira Maria J, Lundkvist Per, Cook Naomi, Lind Lars, Franks Paul W, Fall Tove, Eriksson Jan W, Ingelsson Erik
Abstract excerpt
AIM: To assess practical implications of genotype-based recall (GBR) studies, an increasingly popular approach for in-depth characterization of genotype-phenotype relationships. METHODS: We genotyped 2500 participants from the Swedish EpiHealth cohort and considered loss-of-function and missense variants in genes with relation to cardiometabolic traits as the basis for our GBR study. Therefore, we focused on...
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