Article
Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference.
Nature communications - 19 Feb 2018
Corbin Laura J, Tan Vanessa Y, Hughes David A, Wade Kaitlin H, Paul Dirk S, Tansey Katherine E, Butcher Frances, Dudbridge Frank, Howson Joanna M, Jallow Momodou W, John Catherine, Kingston Nathalie, Lindgren Cecilia M, O'Donavan Michael, O'Rahilly Stephen, Owen Michael J, Palmer Colin N A, Pearson Ewan R, Scott Robert A, van Heel David A, Whittaker John, Frayling Tim, Tobin Martin D, Wain Louise V, Smith George Davey, Evans David M, Karpe Fredrik, McCarthy Mark I, Danesh John, Franks Paul W, Timpson Nicholas J
Abstract excerpt
Detailed phenotyping is required to deepen our understanding of the biological mechanisms behind genetic associations. In addition, the impact of potentially modifiable risk factors on disease requires analytical frameworks that allow causal inference. Here, we discuss the characteristics of Recall-by-Genotype (RbG) as a study design aimed at addressing both these needs. We describe two broad scenarios for the...
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