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Article

Stromal cell-derived factor-1 (CXCL12) activates integrins by direct binding to an allosteric ligand-binding site (site 2) of integrins without CXCR4.

The Biochemical journal - 16 Feb 2018

Fujita Masaaki, Davari Parastoo, Takada Yoko K, Takada Yoshikazu

Abstract excerpt

Leukocyte arrest on the endothelial cell surface during leukocyte extravasation is induced by rapid integrin activation by chemokines. We recently reported that fractalkine induces integrin activation without its receptor CX3CR1 through binding to the allosteric site (site 2) of integrins. Peptides from site 2 bound to fractalkine and suppressed integrin activation by fractalkine. We hypothesized that this is not...

Read the complete abstract on PubMed

Topics

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Share to Allosteric Site
Share to Cell-Free System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemokine CXCL12

Share to CHO Cells

Share to Cricetulus

Share to Integrins

Share to Molecular Docking Simulation

Share to Receptors, CXCR4

Source

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Identifiers

PMID: 29301984
DOI: 10.1042/BCJ20170867
PMCID: PMC7485306

Genes

CXCR4
CXCL12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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