Article
The functions of the flavin contact residues, alphaArg249 and betaTyr16, in human electron transfer flavoprotein.
Biochimica et biophysica acta - 17 Aug 1999
Dwyer T M, Zhang L, Muller M, Marrugo F, Frerman F
Abstract excerpt
Arg249 in the large (alpha) subunit of human electron transfer flavoprotein (ETF) heterodimer is absolutely conserved throughout the ETF superfamily. The guanidinium group of alphaArg249 is within van der Waals contact distance and lies perpendicular to the xylene subnucleus of the flavin ring, near the region proposed to be involved in electron transfer with medium chain acyl-CoA dehydrogenase. The backbone...
Topics
- Acyl-CoA Dehydrogenase
- Acyl-CoA Dehydrogenases
- Animals
- Arginine
- Asparagine
- Circular Dichroism
- Electron Transport
- Electron-Transferring Flavoproteins
- Flavoproteins
- Glutaryl-CoA Dehydrogenase
- Humans
- Hydroquinones
- Kinetics
- Mutagenesis, Site-Directed