Article
The paradox of HBV evolution as revealed from a 16th century mummy.
PLoS pathogens - 1 Jan 2018
Patterson Ross Zoe, Klunk Jennifer, Fornaciari Gino, Giuffra Valentina, Duchêne Sebastian, Duggan Ana T, Poinar Debi, Douglas Mark W, Eden John-Sebastian, Holmes Edward C, Poinar Hendrik N
Abstract excerpt
Hepatitis B virus (HBV) is a ubiquitous viral pathogen associated with large-scale morbidity and mortality in humans. However, there is considerable uncertainty over the time-scale of its origin and evolution. Initial shotgun data from a mid-16th century Italian child mummy, that was previously paleopathologically identified as having been infected with Variola virus (VARV, the agent of smallpox), showed no DNA...
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