Article
Ancient hepatitis B viruses from the Bronze Age to the Medieval period.
Nature - 1 May 2018
Mühlemann Barbara, Jones Terry C, Damgaard Peter de Barros, Allentoft Morten E, Shevnina Irina, Logvin Andrey, Usmanova Emma, Panyushkina Irina P, Boldgiv Bazartseren, Bazartseren Tsevel, Tashbaeva Kadicha, Merz Victor, Lau Nina, Smrčka Václav, Voyakin Dmitry, Kitov Egor, Epimakhov Andrey, Pokutta Dalia, Vicze Magdolna, Price T Douglas, Moiseyev Vyacheslav, Hansen Anders J, Orlando Ludovic, Rasmussen Simon, Sikora Martin, Vinner Lasse, Osterhaus Albert D M E, Smith Derek J, Glebe Dieter, Fouchier Ron A M, Drosten Christian, Sjögren Karl-Göran, Kristiansen Kristian, Willerslev Eske
Abstract excerpt
Hepatitis B virus (HBV) is a major cause of human hepatitis. There is considerable uncertainty about the timescale of its evolution and its association with humans. Here we present 12 full or partial ancient HBV genomes that are between approximately 0.8 and 4.5 thousand years old. The ancient sequences group either within or in a sister relationship with extant human or other ape HBV clades. Generally, the...
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