Article
Different effects of two mutations on the infectivity of Ebola virus glycoprotein in nine mammalian species.
The Journal of general virology - 1 Feb 2018
Kurosaki Yohei, Ueda Mahoko Takahashi, Nakano Yusuke, Yasuda Jiro, Koyanagi Yoshio, Sato Kei, Nakagawa So
Abstract excerpt
Ebola virus (EBOV), which belongs to the genus Ebolavirus, causes a severe and often fatal infection in primates, including humans, whereas Reston virus (RESTV) only causes lethal disease in non-human primates. Two amino acids (aa) at positions 82 and 544 of the EBOV glycoprotein (GP) are involved in determining viral infectivity. However, it remains unclear how these two aa residues affect the infectivity of...
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