Article
Evolutionary determinants of genome-wide nucleotide composition.
Nature ecology & evolution - 1 Feb 2018
Long Hongan, Sung Way, Kucukyildirim Sibel, Williams Emily, Miller Samuel F, Guo Wanfeng, Patterson Caitlyn, Gregory Colin, Strauss Chloe, Stone Casey, Berne Cécile, Kysela David, Shoemaker William R, Muscarella Mario E, Luo Haiwei, Lennon Jay T, Brun Yves V, Lynch Michael
Abstract excerpt
One of the long-standing mysteries of evolutionary genomics is the source of the wide phylogenetic diversity in genome nucleotide composition (G + C versus A + T), which must be a consequence of interspecific differences in mutation bias, the efficiency of selection for different nucleotides or a combination of the two. We demonstrate that although genomic G + C composition is strongly driven by mutation bias, it...
Topics
- Evolution, Molecular
- Gene Conversion
- Genome
- Mutation
- Nucleotides
- Phylogeny