Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structure of the G119S Mutant Acetylcholinesterase of the Malaria Vector Anopheles gambiae Reveals Basis of Insecticide Resistance.

Structure (London, England : 1993) - 2 Jan 2018

Cheung Jonah, Mahmood Arshad, Kalathur Ravi, Liu Lixuan, Carlier Paul R

Abstract excerpt

Malaria is a devastating disease in sub-Saharan Africa and is transmitted by the mosquito Anopheles gambiae. While indoor residual spraying of anticholinesterase insecticides has been useful in controlling the spread of malaria, widespread application of these compounds has led to the rise of an insecticide-resistant mosquito strain that harbors a G119S mutation in the nervous system target enzyme...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Baculoviridae
Share to Cholinesterase Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorides

Share to Ketones

Share to Mosquito Vectors

Share to Protein Conformation, alpha-Helical

Share to Protein Conformation, beta-Strand

Share to Sf9 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 29276037
DOI: 10.1016/j.str.2017.11.021
PMCID: PMC5752620

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structure of the G119S Mutant Acetylcholinesterase of the Malaria Vector Anopheles gambiae Reveals Basis of Insecticide Resistance.PMID 29276037Read ↗

Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase.Semantic proximity Read ↗

The G119S Acetylcholinesterase (Ace-1) Target Site Mutation Confers Carbamate Resistance in the Major Malaria Vector Anopheles gambiae from Cameroon: A Challenge for the Coming IRS ImplementationSemantic proximity Read ↗

Metabolic and target-site mechanisms combine to confer strong DDT resistance in Anopheles gambiae.Semantic proximity Read ↗

Acetylcholinesterase (ace-1R) target site mutation G119S and resistance to carbamates in Anopheles gambiae (sensu lato) populations from Mali.Semantic proximity Read ↗

The unique mutation in <i>ace‐1</i> giving high insecticide resistance is easily detectable in mosquito vectorsSemantic proximity Read ↗

Distribution of acetylcholinesterase (Ace-1R) target-site G119S mutation and resistance to carbamates and organophosphates in Anopheles gambiae sensu lato populations from Cameroon.Semantic proximity Read ↗

An insecticide resistance-breaking mosquitocide targeting inward rectifier potassium channels in vectors of Zika virus and malariaSemantic proximity Read ↗

A tryptophan in the bottleneck of the catalytic gorge of an invertebrate acetylcholinesterase confers relative resistance to carbamate and organophosphate inhibitors.Semantic proximity Read ↗

Structural insights into conformational flexibility at the peripheral site and within the active center gorge of AChE.Semantic proximity Read ↗

Contemporary evolution of resistance at the major insecticide target site gene Ace-1 by mutation and copy number variation in the malaria mosquito Anopheles gambiae.Semantic proximity Read ↗

Insecticide binding mode analysis and biological effects of acetylcholinesterase target-site resistance mutations in Spodoptera frugiperda.Semantic proximity Read ↗

A Wrench in the Works of Human Acetylcholinesterase: Soman Induced Conformational Changes Revealed by Molecular Dynamics SimulationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.