Article
Contemporary evolution of resistance at the major insecticide target site gene Ace-1 by mutation and copy number variation in the malaria mosquito Anopheles gambiae.
Molecular ecology - 1 Jun 2015
Weetman David, Mitchell Sara N, Wilding Craig S, Birks Daniel P, Yawson Alexander E, Essandoh John, Mawejje Henry D, Djogbenou Luc S, Steen Keith, Rippon Emily J, Clarkson Christopher S, Field Stuart G, Rigden Daniel J, Donnelly Martin J
Abstract excerpt
Functionally constrained genes are ideal insecticide targets because disruption is often fatal, and resistance mutations are typically costly. Synaptic acetylcholinesterase (AChE) is an essential neurotransmission enzyme targeted by insecticides used increasingly in malaria control. In Anopheles and Culex mosquitoes, a glycine-serine substitution at codon 119 of the Ace-1 gene confers both resistance and fitness...
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