Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Is there an association between PAWP/WBP2NL sequence, expression, and distribution in sperm cells and fertilization failures in ICSI cycles?

Molecular reproduction and development - 1 Feb 2018

Freour Thomas, Barragan Montserrat, Torra-Massana Marc, Ferrer-Vaquer Anna, Vassena Rita

Abstract excerpt

Successful fertilization in mammals depends on the sperm's ability to initiate intracellular Ca2+ oscillations in the egg, a phenomenon that is elicited by Sperm-oocyte activating factors (SOAFs), whose quantitative and/or qualitative defect might result in fertilization failure. One such proposed factor is Post-acrosomal WW domain-binding protein (PAWP/WBP2NL), although its ability to activate human oocytes has...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fertilization in Vitro
Share to Infertility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Seminal Plasma Proteins

Share to Sperm Injections, Intracytoplasmic

Share to Spermatozoa

Share to Tissue Distribution

Share to Tissue Donors

Share to Treatment Failure

Source

Identifiers

PMID: 29271520
DOI: 10.1002/mrd.22950

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Is there an association between PAWP/WBP2NL sequence, expression, and distribution in sperm cells and fertilization failures in ICSI cycles?PMID 29271520Read ↗

Sperm Postacrosomal WW Domain-Binding Protein Is Not Required for Mouse Egg Activation1Semantic proximity Read ↗

PAWP, a Sperm-specific WW Domain-binding Protein, Promotes Meiotic Resumption and Pronuclear Development during FertilizationSemantic proximity Read ↗

WBP2 shares a common location in mouse spermatozoa with WBP2NL/PAWP and like its descendent is a candidate mouse oocyte activating factorSemantic proximity Read ↗

SPERM FACTORS AND EGG ACTIVATION: Fertilization failure after human ICSI and the clinical potential of PLCZ1Semantic proximity Read ↗

Gene mutations associated with fertilization failure after in vitro fertilization/intracytoplasmic sperm injection.Semantic proximity Read ↗

Homozygous mutation of PLCZ1 leads to defective human oocyte activation and infertility that is not rescued by the WW-binding protein PAWP.Semantic proximity Read ↗

The identification of novel mutations in PLCZ1 responsible for human fertilization failure and a therapeutic intervention by artificial oocyte activationSemantic proximity Read ↗

Sperm Factors and Oocyte Activation: Current Controversies and Considerations1Semantic proximity Read ↗

Novel mutations in WEE2: Expanding the spectrum of mutations responsible for human fertilization failureSemantic proximity Read ↗

Mutational disruption of transcription factors binding and regulatory networks in a case of unexplained total fertilization failure.Semantic proximity Read ↗

Protein expression pattern of PAWP in bull spermatozoa is associated with sperm quality and fertility following artificial inseminationSemantic proximity Read ↗

Diagnosis and Treatment of Male Infertility-Related Fertilization FailureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.