Article
G protein-coupled receptor gpr34l mutation affects thrombocyte function in zebrafish.
British journal of haematology - 1 Feb 2018
Kim Seongcheol, Alsrhani Abdullah, Zafreen Lala, Khandekar Gauri, Marlow Florence L, Abrams Elliott W, Mullins Mary C, Jagadeeswaran Pudur
Abstract excerpt
Haemostasis is a defence mechanism that has evolved to protect organisms from losing their circulating fluid. We have previously introduced zebrafish as a model to study the genetics of haemostasis to identify novel genes that play a role in haemostasis. Here, we identify a zebrafish mutant that showed prolonged time to occlusion (TTO) in the laser injury venous thrombosis assay. By linkage analysis and fine...
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