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Article

Hypoxic 3D in vitro culture models reveal distinct resistance processes to TKIs in renal cancer cells

1 Dec 2017

Abstract excerpt

The aim of this study is to determine the effect of hypoxia on axitinib and sorafenib-treated renal cell carcinoma (RCC) cells. Hypoxia is a crucial factor influencing transcription process via protein modulation, which was shown i.e. in pancreatic cancer. Until now, hypoxia has been defined as associated with poorer outcome and inducing chemotherapy resistance in solid tumors. The unique phenomenon of...

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PMID: 29270287
DOI: 10.1186/s13578-017-0197-8

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