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Article

Human pericytes adopt myofibroblast properties in the microenvironment of the IPF lung.

JCI insight - 21 Dec 2017

Sava Parid, Ramanathan Anand, Dobronyi Amelia, Peng Xueyan, Sun Huanxing, Ledesma-Mendoza Adrian, Herzog Erica L, Gonzalez Anjelica L

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a fatal disease of unknown etiology characterized by a compositionally and mechanically altered extracellular matrix. Poor understanding of the origin of α-smooth muscle actin (α-SMA) expressing myofibroblasts has hindered curative therapies. Though proposed as a source of myofibroblasts in mammalian tissues, identification of microvascular pericytes (PC) as contributors to...

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Identifiers

PMID: 29263297
DOI: 10.1172/jci.insight.96352
PMCID: PMC5752282

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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