Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss-of-Function Mutations in Calcitonin Receptor ( CALCR ) Identify Highly Aggressive Glioblastoma with Poor Outcome

20 Dec 2017

Abstract excerpt

Abstract Purpose: Despite significant advances in the understanding of the biology, the prognosis of glioblastoma (GBM) remains dismal. The objective was to carry out whole-exome sequencing (WES) of Indian glioma and integrate with that of TCGA to find clinically relevant mutated pathways. Experimental Design: WES of different astrocytoma samples (n = 42; Indian cohort) was carried out and compared with that of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to Glioma Diagnosis and Treatment
Share to Neuroblastoma Research and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29263181
DOI: 10.1158/1078-0432.ccr-17-1901

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss-of-Function Mutations in Calcitonin Receptor ( CALCR ) Identify Highly Aggressive Glioblastoma with Poor OutcomePMID 29263181Read ↗

Calcitonin-Driven Reactivation of the Hippo Tumor-Suppressor Cascade Attenuates YAP/TAZ Oncogenic Signaling in GlioblastomaSemantic proximity Read ↗

G-protein Coupled Receptor 34 Promotes Gliomagenesis by Inducing Proliferation and Malignant Phenotype via TGF-Beta/Smad Signaling Pathway.Semantic proximity Read ↗

Molecular Determinants of Calcitriol Signaling and Sensitivity in Glioma Stem-like CellsSemantic proximity Read ↗

Modeling craniopharyngioma for drug screening reveals a neuronal mechanism for tumor growthSemantic proximity Read ↗

Novel Glial Cells Missing-2 (GCM2) variants in parathyroid disorders.Semantic proximity Read ↗

Transmembrane CLIC1 sustains EGFRvIII–STAT3 oncogenic signaling in Glioblastoma through interaction with OSMRSemantic proximity Read ↗

An OSMR-CLIC1 cross talk drives key oncogenic pathways in glioblastomaSemantic proximity Read ↗

The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer.Semantic proximity Read ↗

Vitamin D3 suppresses the cholesterol homeostasis pathway in patient‐derived glioma cell linesSemantic proximity Read ↗

Polymorphisms in the calcium-sensing receptor gene are associated with clinical outcome of neuroblastoma.Semantic proximity Read ↗

Glial cells missing-2 (GCM2) transactivates the calcium-sensing receptor gene: effect of a dominant-negative GCM2 mutant associated with autosomal dominant hypoparathyroidism.Semantic proximity Read ↗

GNAS mutations suppress the cell invasion through regulating EMT by activating the MEG3/Wnt/β-catenin pathway in growth hormone-secreting pituitary adenomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.