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HSPA5 negatively regulates lysosomal activity through ubiquitination of MUL1 in head and neck cancer

20 Dec 2017

Abstract excerpt

HSPA5/GRP78/BiP plays an important role in cell survival or tumor progression. For these reasons, HSPA5 is an emerging therapeutic target in cancer development. Here we report that HSPA5 contributes to head and neck cancer (HNC) survival via maintenance of lysosomal activity; however, a nonthermal plasma (NTP, considered as a next-generation cancer therapy)-treated solution (NTS) inhibits HNC progression through...

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PMID: 29260979
DOI: 10.1080/15548627.2017.1414126

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