Article
Mutations in SELENBP1, encoding a novel human methanethiol oxidase, cause extraoral halitosis.
Nature genetics - 1 Jan 2018
Pol Arjan, Renkema G Herma, Tangerman Albert, Winkel Edwin G, Engelke Udo F, de Brouwer Arjan P M, Lloyd Kent C, Araiza Renee S, van den Heuvel Lambert, Omran Heymut, Olbrich Heike, Oude Elberink Marijn, Gilissen Christian, Rodenburg Richard J, Sass Jörn Oliver, Schwab K Otfried, Schäfer Hendrik, Venselaar Hanka, Sequeira J Silvia, Op den Camp Huub J M, Wevers Ron A
Abstract excerpt
Selenium-binding protein 1 (SELENBP1) has been associated with several cancers, although its exact role is unknown. We show that SELENBP1 is a methanethiol oxidase (MTO), related to the MTO in methylotrophic bacteria, that converts methanethiol to H2O2, formaldehyde, and H2S, an activity not previously known to exist in humans. We identified mutations in SELENBP1 in five patients with cabbage-like breath odor....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.