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Article

Intact Cell Mass Spectrometry as a Quality Control Tool for Revealing Minute Phenotypic Changes of Cultured Human Embryonic Stem Cells.

Stem cells translational medicine - 1 Jan 2018

Vaňhara Petr, Kučera Lukáš, Prokeš Lubomír, Jurečková Lucie, Peña-Méndez Eladia María, Havel Josef, Hampl Aleš

Abstract excerpt

The stability of in vitro cell cultures is an important issue for any clinical, bio-industrial, or pharmacological use. Embryonic stem cells are pluripotent; consequently, they possess the ability to differentiate into all three germ layers and are inherently prone to respond to differentiation stimuli. However, long-term culture inevitably yields clones that are best adapted to the culture conditions, passaging...

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Identifiers

PMID: 29248004
DOI: 10.1002/sctm.17-0107
PMCID: PMC5746154

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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