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Article

The KL-VS polymorphism of KLOTHO gene is protective against retinopathy incidence in patients with type 1 diabetes.

Biochimica et biophysica acta. Molecular basis of disease - 1 Mar 2018

Słomiński Bartosz, Ryba-Stanisławowska Monika, Skrzypkowska Maria, Myśliwska Jolanta, Myśliwiec Małgorzata

Abstract excerpt

BACKGROUND AND AIMS: KLOTHO is an anti-ageing circulating hormone involved in insulin signaling, inflammation and vascular homeostasis through its protective effects on the endothelium and antioxidant actions. The common functional "KL-VS" variant of the KLOTHO gene is reproducibly associated with longevity in humans. Large number of studies have evaluated close relationship between KLOTHO protein and diabetes...

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Identifiers

PMID: 29247834
DOI: 10.1016/j.bbadis.2017.12.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The KL-VS polymorphism of KLOTHO gene is protective against retinopathy incidence in patients with type 1 diabetes.PMID 29247834Read ↗

A new potential mode of cardiorenal protection of KLOTHO gene variability in type 1 diabetic adolescents.Semantic proximity Read ↗

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Influence of Klotho gene polymorphisms on vascular gene expression and its relationship to cardiovascular disease.Semantic proximity Read ↗

The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians.Semantic proximity Read ↗

Association of Klotho polymorphisms with healthy aging: a systematic review and meta-analysis.Semantic proximity Read ↗

The frequency of Klotho KL-VS polymorphism in a large Italian population, from young subjects to centenarians, suggests the presence of specific time windows for its effect.Semantic proximity Read ↗

Klotho KL-VS genotype is involved in blood pressure regulation.Semantic proximity Read ↗

Association of exonic variants of Klotho with metabolic syndrome in Asian Indians.Semantic proximity Read ↗

Absence of kl-vs variant of klotho gene in Iranian cardiac patients (comparison to the world populations).Semantic proximity Read ↗

Circulating CD34+ and CD34+VEGFR2+ progenitor cells are associated with KLOTHO KL-VS polymorphism.Semantic proximity Read ↗

Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity.Semantic proximity Read ↗

Klotho expression in peripheral blood circulating cells is associated with vascular and systemic inflammation in atherosclerotic vascular diseaseSemantic proximity Read ↗

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