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Article

A new potential mode of cardiorenal protection of KLOTHO gene variability in type 1 diabetic adolescents.

Journal of molecular medicine (Berlin, Germany) - 1 Jul 2020

Słomiński Bartosz, Ryba-Stanisławowska Monika, Skrzypkowska Maria, Gabig-Cimińska Magdalena, Myśliwiec Małgorzata

Abstract excerpt

As the KL-VS haplotype alters secretion and activity of KLOTHO and uric acid (UA) is associated with endothelial dysfunction and inflammation, their mutual links may contribute to microalbuminuria (MA) in patients with type 1 diabetes (T1D). Therefore, we hypothesize that KL-VS polymorphism could be associated with the prevalence of MA in T1D patients, and KL-VS polymorphism could modify physiological functions...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32435919
DOI: 10.1007/s00109-020-01918-7
PMCID: PMC7343757

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A new potential mode of cardiorenal protection of KLOTHO gene variability in type 1 diabetic adolescents.PMID 32435919Read ↗

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