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Article

Altered expression of telomere-associated genes in leukocytes among BRCA1 and BRCA2 carriers.

Molecular carcinogenesis - 1 Apr 2018

Tanaka Hiromi, Phipps Elizabeth A, Wei Ting, Wu Xi, Goswami Chirayu, Liu Yunlong, Sledge George W, Mina Lida, Herbert Brittney-Shea

Abstract excerpt

Telomere dysfunction resulting from telomere shortening and deregulation of shelterin components has been linked to the pathogenesis of age-related disorders, including cancer. Recent evidence suggests that BRCA1/2 (BRCA1 and BRCA2) tumor suppressor gene products play an important role in telomere maintenance. Although telomere shortening has been reported in BRCA1/2 carriers, the direct effects of BRCA1/2...

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Source

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Identifiers

PMID: 29240257
DOI: 10.1002/mc.22773
PMCID: PMC5832588

Genes

BRCA1
BRCA2
TINF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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